Description
Product Characteristics:
Aliases: Putative MAPK activating protein PM14 antibody, Putative MAPK-activating protein PM14 antibody, Putative NF kappa B activating protein 20 antibody, Putative NF-kappa-B-activating protein 20 antibody, T2BP antibody, TIFA antibody, TIFA_HUMAN antibody, TRAF interacting protein with FHA domain containing protein A antibody, TRAF-interacting protein with FHA domain-containing protein A antibody, TRAF2 binding protein antibody, TRAF2-binding protein antibody
Target Information: Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (By similarity)